Journal of Pathology and Translational Medicine

Original Article

Membranous Insulin-like Growth Factor-1 Receptor (IGF1R) Expression Is Predictive of Poor Prognosis in Patients with Epidermal Growth Factor Receptor (EGFR)-Mutant Lung Adenocarcinoma: Eunhyang Park, Soo Young Park, Hyojin Kim, Ping-Li Sun, Yan Jin, Suk Ki Cho, Kwhanmien Kim, Choon-Taek Lee, Jin-Haeng Chung; J Pathol Transl Med. 2015;49(5):382-388. Published online August 4, 2015; DOI: https://doi.org/10.4132/jptm.2015.07.10

7,785 View
74 Download
22 Web of Science
17 Crossref

Background
Insulin-like growth factor-1 receptor (IGF1R) is a membrane receptor-type tyrosine kinase that has attracted considerable attention as a potential therapeutic target, although its clinical significance in non-small cell lung cancer (NSCLC) is controversial. This study aimed to clarify the clinical significance of IGF1R expression in human NSCLC. Methods: IGF1R protein expression was evaluated using immunohistochemistry in 372 patients with NSCLC who underwent curative surgical resection (146 squamous cell carcinomas [SqCCs] and 226 adenocarcinomas [ADCs]). We then analyzed correlations between expression of IGF1R and clinicopathological and molecular features and prognostic significance. Results: Membranous and cytoplasmic IGF1R expression were significantly higher in SqCCs than in ADCs. In patients with SqCC, membranous IGF1R expression was associated with absence of vascular, lymphatic, and perineural invasion; lower stage; and better progression-free survival (PFS) (hazard ratio [HR], 0.586; p = .040). In patients with ADC, IGF1R expression did not have a significant prognostic value; however, in the subgroup of epidermal growth factor receptor (EGFR)-mutant ADC, membranous IGF1R expression was associated with lymphatic and perineural invasion, solid predominant histology, and higher cancer stage and was significantly associated with worse PFS (HR, 2.582; p = .009). Conclusions: Lung ADC and SqCC showed distinct IGF1R expression profiles that demonstrated prognostic significance. High membranous IGF1R expression was predictive of poor PFS in EGFR-mutant lung ADC, while it was predictive of better PFS in SqCC. These findings will help improve study design for subsequent investigations and select patients for future anti-IGF1R therapy.

Citations

Citations to this article as recorded by

Expression of Amine Oxidase Proteins in Adrenal Cortical Neoplasm and Pheochromocytoma
Eun Kyung Kim, Ja Seung Koo
Biomedicines.2023; 11(7): 1896. CrossRef
Expression of EMP 1, 2, and 3 in Adrenal Cortical Neoplasm and Pheochromocytoma
Yoon Jin Cha, Ja Seung Koo
International Journal of Molecular Sciences.2023; 24(16): 13016. CrossRef
Clinico-pathological characteristics of IGFR1 and VEGF-A co-expression in early and locally advanced-stage lung adenocarcinoma
Wenting Liu, Junling Xia, Qingwu Du, Jingya Wang, Ting Mei, Tingting Qin
Journal of Cancer Research and Clinical Oncology.2023; 149(18): 16365. CrossRef
NT157 exerts antineoplastic activity by targeting JNK and AXL signaling in lung cancer cells
Lívia Bassani Lins de Miranda, Keli Lima, Juan Luiz Coelho-Silva, Fabiola Traina, Susumu S. Kobayashi, João Agostinho Machado-Neto
Scientific Reports.2022;[Epub] CrossRef
IRS2 Amplification as a Predictive Biomarker in Response to Ceritinib in Small Cell Lung Cancer
Mi-Sook Lee, Kyungsoo Jung, Ji-Young Song, Min-Jung Sung, Sung-Bin Ahn, Boram Lee, Doo-Yi Oh, Yoon-La Choi
Molecular Therapy - Oncolytics.2020; 16: 188. CrossRef
Understanding Lineage Plasticity as a Path to Targeted Therapy Failure in EGFR-Mutant Non-small Cell Lung Cancer
Tatiana Shaurova, Letian Zhang, David W. Goodrich, Pamela A. Hershberger
Frontiers in Genetics.2020;[Epub] CrossRef
Characterization of head and neck squamous cell carcinoma arising in young patients: Particular focus on molecular alteration and tumor immunity
Hyang Joo Ryu, Eun Kyung Kim, Byoung Chul Cho, Sun Och Yoon
Head & Neck.2019; 41(1): 198. CrossRef
Investigating Trk Protein Expression between Oropharyngeal and Non-oropharyngeal Squamous Cell Carcinoma: Clinical Implications and Possible Roles of Human Papillomavirus Infection
Yoon Ah Cho, Ji Myung Chung, Hyunmi Ryu, Eun Kyung Kim, Byoung Chul Cho, Sun Och Yoon
Cancer Research and Treatment.2019; 51(3): 1052. CrossRef
NOVA1 induction by inflammation and NOVA1 suppression by epigenetic regulation in head and neck squamous cell carcinoma
Eun Kyung Kim, Yoon Ah Cho, Mi-kyoung Seo, Hyunmi Ryu, Byoung Chul Cho, Yoon Woo Koh, Sun Och Yoon
Scientific Reports.2019;[Epub] CrossRef
Advances in studies of tyrosine kinase inhibitors and their acquired resistance
Qinlian Jiao, Lei Bi, Yidan Ren, Shuliang Song, Qin Wang, Yun-shan Wang
Molecular Cancer.2018;[Epub] CrossRef
The long coding RNA AFAP1-AS1 promotes tumor cell growth and invasion in pancreatic cancer through upregulating the IGF1R oncogene via sequestration of miR-133a
Bo Chen, Qinhua Li, Yongping Zhou, Xujing Wang, Qiqi Zhang, Yongkun Wang, Huiren Zhuang, Xiaohua Jiang, Wujun Xiong
Cell Cycle.2018; 17(16): 1949. CrossRef
Overexpression of lncRNA EGFR‑AS1 is associated with a poor prognosis and promotes chemotherapy resistance in non‑small cell lung cancer
Yu-Hua Xu, Jian-Ren Tu, Tian-Tian Zhao, Shi-Guang Xie, Sheng-Bo Tang
International Journal of Oncology.2018;[Epub] CrossRef
IGF-IR signaling in epithelial to mesenchymal transition and targeting IGF-IR therapy: overview and new insights
Heming Li, Izhar Singh Batth, Xiujuan Qu, Ling Xu, Na Song, Ruoyu Wang, Yunpeng Liu
Molecular Cancer.2017;[Epub] CrossRef
Insulin-like growth factor 1 receptor expression in advanced non-small-cell lung cancer and its impact on overall survival
Mojca Humar, Izidor Kern, Gregor Vlacic, Vedran Hadzic, Tanja Cufer
Radiology and Oncology.2017; 51(2): 195. CrossRef
IGF1R depletion facilitates MET-amplification as mechanism of acquired resistance to erlotinib in HCC827 NSCLC cells
Dianna Hussmann, Anne Tranberg Madsen, Kristine Raaby Jakobsen, Yonglun Luo, Boe Sandahl Sorensen, Anders Lade Nielsen
Oncotarget.2017; 8(20): 33300. CrossRef
Upregulated Neuro-oncological Ventral Antigen 1 (NOVA1) Expression Is Specific to Mature and Immature T- and NK-Cell Lymphomas
Eun Kyung Kim, Sun Och Yoon, Soo Hee Kim, Woo Ick Yang, Yoon Ah Cho, Soo Jeong Kim
Journal of Pathology and Translational Medicine.2016; 50(2): 104. CrossRef
The Clinical Significance of the Insulin-Like Growth Factor-1 Receptor Polymorphism in Non-Small-Cell Lung Cancer with Epidermal Growth Factor Receptor Mutation
Tu-Chen Liu, Ming-Ju Hsieh, Ming-Che Liu, Whei-Ling Chiang, Thomas Tsao, Shun-Fa Yang
International Journal of Molecular Sciences.2016; 17(5): 763. CrossRef

Case Reports

Metaplastic Thymoma: Report of 4 Cases: Guhyun Kang, Nara Yoon, Joungho Han, Young Eun Kim, Tae Sung Kim, Kwhanmien Kim; Korean J Pathol. 2012;46(1):92-95. Published online February 23, 2012; DOI: https://doi.org/10.4132/KoreanJPathol.2012.46.1.92

7,834 View
61 Download
14 Crossref

Abstract PDF

Metaplastic thymoma (MT), accepted in the World Health Organization 2004 scheme, is a circumscribed tumor of the thymus exhibiting biphasic morphology. We herein describe the clinicopathologic features of four MTs and the differential diagnoses of this unusual tumor. There were three women and one man with mean age of 49.5 years. The patients were found to have mediastinal masses, and underwent surgical excision. One exhibited symptoms of myasthenia gravis, and the serum titer for anti-acetylcholine receptor antibody was positive. Grossly, the tumors were encapsulated, and showed vaguely multinodular, solid, tan-white to yellow cut surfaces. Histologically, they comprised epithelial islands intertwining with bundles of delicate spindle cells. The patients remained well after surgical excision at 5-55 months. Because of the distinctive histological appearance and benign clinical course, MT should be distinguished from other more aggressive mediastinal neoplasms displaying biphasic feature.

Citations

Citations to this article as recorded by

A Rare Case of Metaplastic Thymoma Presenting With Myasthenia Gravis
Ilianne Vega Prado, John Shymansky, Anisha Apte, Keith Mortman, Henry J. Kaminski, Stephanie Barak
International Journal of Surgical Pathology.2024; 32(1): 155. CrossRef
Thymic epithelial tumours: histopathological classification and differential diagnosis
Jan von der Thüsen
Histopathology.2024; 84(1): 196. CrossRef
Epigenetics of Thymic Epithelial Tumors
Vanessa Nicolì, Fabio Coppedè
Cancers.2023; 15(2): 360. CrossRef
Expanding the Clinicopathologic Spectrum of YAP1::MAML2–Rearranged Thymic Neoplasm
Eric Eunshik Kim, Ye Yoon Suh, Sang Won Lee, Jeong Mo Bae, Kyoungbun Lee, Sungyoung Lee, Hongseok Yun, Kyeong Cheon Jung, Jiwon Koh
Modern Pathology.2023; 36(2): 100048. CrossRef
Significance of YAP1–MAML2 rearrangement and GTF2I mutation in the diagnosis and differential diagnosis of metaplastic thymoma
Minghao Wang, Hongtao Xu, Qiang Han, Liang Wang
Annals of Medicine.2023;[Epub] CrossRef
Loss of YAP1 C‐terminus expression as an ancillary marker for metaplastic thymoma: a potential pitfall in detecting YAP1::MAML2 gene rearrangement
Xuan Wang, Lei‐lei Liu, Qing Li, Qiu‐yuan Xia, Rui Li, Sheng‐bing Ye, Ru‐song Zhang, Ru Fang, Hui Chen, Nan Wu, Qiu Rao
Histopathology.2023; 83(5): 798. CrossRef
A Case of Metaplastic Thymoma
Ryoichi TAKENAKA, Kenji NEZU, Daijiro TAKEMOTO, Tatsuya HAYASHI, Hisato YAMAMOTO, Shoichi MATSUKAGE
Nihon Rinsho Geka Gakkai Zasshi (Journal of Japan Surgical Association).2023; 84(4): 538. CrossRef
Malignant Transformation of Metaplastic Thymoma into High-Grade Sarcomatoid Carcinoma: A Case Report
Zheng Hua Piao, Jin Ping Chen, Hai Ren Chen, Xin Cheng Zhou
International Journal of Surgical Pathology.2022; 30(5): 564. CrossRef
YAP1-MAML2 Fusion as a Diagnostic Biomarker for Metaplastic Thymoma
Jikai Zhao, Ruiying Zhao, Chan Xiang, Jinchen Shao, Lianying Guo, Yuchen Han
Frontiers in Oncology.2021;[Epub] CrossRef
Metaplastic thymoma: a distinctive thymic neoplasm characterized by YAP1-MAML2 gene fusions
Marina Vivero, Phani Davineni, Valentina Nardi, John K.C. Chan, Lynette M. Sholl
Modern Pathology.2020; 33(4): 560. CrossRef
Metaplastic thymoma: Report of two cases
Yoshikazu Shinohara, Mariko Tanaka, Kentaro Kitano, Kazuhiro Nagayama, Masaaki Sato, Jun Nakajima
The Journal of the Japanese Association for Chest Surgery.2020; 34(7): 733. CrossRef
Type AB thymoma is not a mixed tumor of type A and type B thymomas, but a distinct type of thymoma
Yukari Miki, Kana Hamada, Tadashi Yoshino, Katsuya Miyatani, Kiyoshi Takahashi
Virchows Archiv.2014; 464(6): 725. CrossRef
Potential Role of Adjuvant Radiation Therapy in Cervical Thymic Neoplasm Involving Thyroid Gland or Neck
Jae Myoung Noh, Sang Yun Ha, Yong Chan Ahn, Dongryul Oh, Seung Won Seol, Young Lyun Oh, Joungho Han
Cancer Research and Treatment.2014; 47(3): 436. CrossRef
A Case of Metaplastic Thymoma
Eiji MIYAHARA, Tomoko ITAGAKI, Masaki KUWAHARA, Akira KAMEDA, Yoshihiro MIYATA, Kazuhiro SENTANI, Wataru YASUI
Nihon Rinsho Geka Gakkai Zasshi (Journal of Japan Surgical Association).2014; 75(2): 360. CrossRef

Solitary Pulmonary Lymphangioma in an Adult: A Brief Case Report.: Hye Jong Song, Joungho Han, Kwhanmien Kim, Kyung Soo Lee, Jinwon Seo; Korean J Pathol. 2008;42(2):125-127.

1,618 View
17 Download

Abstract PDF: Solitary pulmonary lymphangiomas are extremely rare. We report here on an unique case of solitary pulmonary lymphangioma in an adult. A well-circumscribed, 6 cm-sized, pleural based lesion with fluid attenuation was found in a 50-year-old Korean male. He had no previous history of disease or trauma. The wedge-resected lung revealed an ill-demarcated lesion with multiple microscopic cysts and the cystic walls had loose intervening stroma.

First
Prev
Page of 1
Next
Last

Search